HEPATITIS B VIRUS SUPPRESSES COMPLEMENT C9 SYNTHESIS BY LIMITING THE AVAILABILITY OF TRANSCRIPTION FACTOR USF-1 AND INHIBITS FORMATION OF MEMBRANE ATTACK COMPLEX: IMPLICATIONS IN DISEASE PATHOGENESIS

Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis

Abstract Background The complement system functions primarily as a first-line host defense against invading microbes, including viruses.However, the interaction of Hepatitis B virus (HBV) with the complement-components during chronic HBV infection remains largely unknown.We investigated the mechanism by which HBV inhibits the formation of cytolytic

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Correlation between measured and calculated free phenytoin serum concentration in neurointensive care patients with hypoalbuminemia

Seyyede-Sareh Javadi,1 Reza Mahjub,2 Abbas Taher,3 Younes Mohammadi,4 Maryam Mehrpooya1 1Department of Clinical Pharmacy, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran; 3Department of Anesthesiology and Critical Care,

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The Serological Prevalence of Rabies Virus-Neutralizing Antibodies in the Bat Population on the Caribbean Island of Trinidad

Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean.The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population.We aimed to determine the seroprevalence of rabies virus neutralizing antibodies (RVNA) in light of spatio

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